CHARACTERISATION OF PREPARED CEFIXIME AND METRONIDAZOLE WITH CHITOSAN NANOPARTICLE FOR PHARMACEUTICAL APPLICATION

Naturally existing polymer compounds, particularly polysaccharide polymers, have
been employed in pharmaceuticals to deliver a wide range of therapeutic medicines.
Next to cellulose-β-(1,4) linked N-acetyl-D-glucosamine units, chitosan is the second
most prevalent naturally occurring polysaccharide. It is a mucoadhesive polymer that
is biocompatible and biodegradable and has been widely used in the creation of both
micro- and nanoparticles. Natural polymers made of randomly arranged N-acetyl-
D-glucosamine (acetylated unit) and deacetyl-D-glucosamine (deacetylated unit)
are chitin and its deacetylated derivative chitosan. Due to the free protonable amino
groups found in the D-glucosamine units, chitosan is soluble in acidic environments
whereas chitin is insoluble in aqueous media. Chitosan is a particularly promising
source for pharmaceutical application. Applications of chitosan as a wound dressing
material include development of antimicrobial agents, chitosan bandage for wound
healing, suitable for starting material for wound dressings, its hemostatic effect -ability
to inhibit microbial growth. Chitosan is biodegradable non-toxic natural polymer
that promotes wound healing and can be used as antibiotics for bacterial control by
chitosan-based wound dressings. Due to its inherent antibacterial qualities and capacity
to transfer extrinsic antimicrobial agents to wounds and burns, chitosan is used to
treat wound and burn infections.
Keywords: chitin, biocompatibility, biodegradable, wound healing.