Facile synthesis of silver nanoparticles using the Simarouba glauca leaf extract and their impact on biological outcomes: A novel perspective for nano-drug development

Nowadays, novel green metal-based nanoparticles are receiving global research interest for their potential utilization in several fields, including the formation of nanoparticles for medical treatment. This work reports a synthesis of silver nanoparticles (AgNPs) using Simarouba glauca (Sg). The obtained Sg-AgNPs were characterized by UV–visible, FTIR, XRD and SEM. Furthermore, the biological properties of synthesized Sg-AgNPs were investigated for reverse mutation, antimicrobial properties, biofilm analysis, hemolytic activities, DNA fragmentation and MTT assay on HeLa cells. The results revealed a biological efficacy of Sg-AgNPs between 25 and 400 μg/mL concentrations. They showed excellent permeability and a promising drug delivery medium.